Radiography
Volume 13 , Pages e31-e44 , December 2007

Contrast-enhanced magnetic resonance angiography: Current status, theoretical limitations and future potential

Received 25 April 2007 ,Revised 1 September 2007 ,Accepted 5 September 2007.

References 

  1. Waugh JR, Sacharia N. Arteriographic complications in the DSA era. Radiology. 1992;182:243–246
  2. Gerhard-Herman M, Gardin JM, Jaff M, Mohler E, Roman M, Naqvi TZ, et al. Guidelines for noninvasive vascular laboratory testing: a report from the American Society of Echocardiography and the Society for Vascular Medicine and Biology. Vasc Med. 2006 Nov;11(3):183–200
  3. Brobeck BR, Forero NP, Romero JM. Practical noninvasive neurovascular imaging of the neck arteries in patients with stroke, transient ischemic attack, and suspected arterial disease that may lead to ischemia, infarction, or flow abnormalities. Semin Ultrasound CT MR. 2006 Jun;27(3):177–193
  4. Dumoulin CL, Cline HE, Souza SP, Wagle WA, Walker MF. Three-dimensional time-of-flight magnetic resonance angiography using spin-saturation. Magn Reson Med. 1989;11:139–149
  5. Haacke EM, Masaryk TJ. The salient features of MR angiography. Radiology. 1989;173:611–612
  6. Masaryk TJ, Tkach J, Glicklich M. Flow, radiofrequency, pulse sequences, and gradient magnetic fields: basic interactions and adaptations to angiographic imaging. Top Magn Reson Imaging. 1991;3:1–11
  7. Keller P. Time of flight magnetic resonance angiography. Neuroimaging Clin N Am. 1992;4:639–656
  8. Dumoulin CL. Phase contrast MR angiography techniques. Magn Reson Imaging Clin N Am. 1995;3:399–411
  9. Jara H, Barish MA. Black-blood MR angiography. Techniques and clinical applications. Magn Reson Imaging Clin N Am. 1999;7:303–317
  10. Scarabino T, Carriero A, Magarelli N, Nemore F, Florio F, D'Angelo V, et al. Magnetic resonance angiography in stenosing-occlusive diseases of the carotid arteries: 3D with time of flight versus 3D with phase contrast. Radiol Med (Torino). 1997;93:214–217
  11. Prince MR. Gadolinium-enhanced MR aortography. Radiology. 1994 Apr;191(1):155–164
  12. Prince MR, Narasimham DL, Stanley JC, Chenevert TL, Williams DM, Marx MV, et al. Breath-hold gadolinium-enhanced MR angiography of the abdominal aorta and its major branches. Radiology. 1995 Dec;197(3):785–792
  13. Prince MR, Narasimham DL, Stanley JC, Wakefield TW, Messina LM, Zelenock GB, et al. Gadolinium-enhanced magnetic resonance angiography of abdominal aortic aneurysms. J Vasc Surg. 1995 Apr;21(4):656–669
  14. Prince MR, Narasimham DL, Jacoby WT, Williams DM, Cho KJ, Marx MV, et al. Three-dimensional gadolinium-enhanced MR angiography of the thoracic aorta. AJR Am J Roentgenol. 1996 Jun;166(6):1387–1397
  15. Prince MR. Body MR angiography with gadolinium contrast agents. Magn Reson Imaging Clin N Am. 1996 Feb;4(1):11–24
  16. Maki JH, Prince MR, Londy FJ, Chenevert TL. The effects of time varying intravascular signal intensity and k-space acquisition order on three-dimensional MR angiography image quality. J Magn Reson Imaging. 1996 Jul–Aug;6(4):642–651
  17. Meaney JF, Weg JG, Chenevert TL, Stafford-Johnson D, Hamilton BH, Prince MR. Diagnosis of pulmonary embolism with magnetic resonance angiography. N Engl J Med. 1997 May 15;336(20):1422–1427
  18. Meaney JF, Prince MR, Nostrant TT, Stanley JC. Gadolinium-enhanced MR angiography of visceral arteries in patients with suspected chronic mesenteric ischemia. J Magn Reson Imaging. 1997 Jan–Feb;7(1):171–176
  19. Prince MR. Why inject contrast for magnetic resonance angiography?. Invest Radiol. 1998 Sep;33(9):483–484
  20. Prince MR. Contrast-enhanced MR angiography: theory and optimization. Magn Reson Imaging Clin N Am. 1998 May;6(2):257–267
  21. Prince MR, Schoenberg SO, Ward JS, Londy FJ, Wakefield TW, Stanley JC. Hemodynamically significant atherosclerotic renal artery stenosis: MR angiographic features. Radiology. 1997;205:128–136
  22. Schoenberg SO, Knopp MV, Londy F, Frishnan S, Zuna I, Lang N, et al. Morphologic and functional magnetic resonance imaging of renal artery stenosis: a multireader tricenter study. J Am Soc Nephrol. 2002;13:158–169
  23. Leiner T, Nelemans PJ, de Haan MW, de Leeuw P, van Engelshoven JMA, Vasbinder GBC. Addition of phase-contrast data to anatomical evaluation substantially improves the diagnostic accuracy of dynamic contrast-enhanced renal MR angiography for the detection of renal artery stenosis. Radiological Society of North America Annual Meeting Abstract Book 2006. p. 540.
  24. Sevick RJ, Tsuruda JS, Schmalbrock P. Three-dimensional time-of-flight MR angiography in the evaluation of cerebral aneurysms. J Comput Assist Tomogr. 1990 Nov–Dec;14(6):874–881
  25. Horikoshi T, Fukamachi A, Nishi H, Fukasawa I. Detection of intracranial aneurysms by three-dimensional time-of-flight magnetic resonance angiography. Neuroradiology. 1994 Apr;36(3):203–207
  26. Brugieres P, Blustajn J, Le Guerinel C, Meder JF, Thomas P, Gaston A. Magnetic resonance angiography of giant intracranial aneurysms. Neuroradiology. 1998 Feb;40(2):96–102
  27. Parker DL, Goodrich KC, Alexander AL, Buswell HR, Blatter DD, Tsuruda JS. Optimized visualization of vessels in contrast enhanced intracranial MR angiography. Magn Reson Med. 1998;40:873–882
  28. Goyen M, Ruehm SG, Debatin JF. MR-angiography: the role of contrast agents. Eur J Radiol. 2000;34:247–256
  29. Laub G. Principles of contrast-enhanced MR angiography: basic and clinical applications. Magn Reson Imaging Clin N Am. 1999;7:783–795
  30. Davis CP, Hany TF, Wildermuth S, Schmidt M, Debatin JF. Postprocessing techniques for gadolinium-enhanced three-dimensional MR angiography. RadioGraphics. 1997;17:1061–1077
  31. Prince MR, Chenevert TL, Foo TK, Londy FJ, Ward JS, Maki JH. Contrast-enhanced abdominal MR angiography: optimization of imaging delay time by automating the detection of contrast material arrival in the aorta. Radiology. 1997;203:109–114
  32. Willinek WA, Gieseke J, Conrad R, Strunk H, Hoogeveen R, von Falkenhausen M, et al. Randomly segmented central k-space ordering in high-spatial-resolution contrast-enhanced MR angiography of the supraaortic arteries: initial experience. Radiology. 2002;225:583–588
  33. Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P. SENSE: sensitivity encoding for fast MRI. Magn Reson Med. 1999;42:952–962
  34. Glockner JF, Hu HH, Stanley DW, Angelos L, King K. Parallel MR imaging: a user's guide. RadioGraphics. 2005;25:1279–1297
  35. Blaimer M, Breuer F, Mueller M, Heidemann RM, Griswold MA, Jakob PM, et al. SMASH, SENSE, PILS, GRAPPA. How to choose the optimal method. Top Magn Reson Imaging. 2004;15:223–236
  36. Wilson GJ, Hoogeveen RM, Willinek WA, Muthupillai R, Maki JH. Parallel imaging in MR angiography. Top Magn Reson Imaging. 2004;15:169–185
  37. Willinek WA, Bayer T, Gieseke J, von Falkenhausen M, Sommer T, Hoogeveen R, et al. High spatial resolution contrast-enhanced MR angiography of the supraaortic arteries using the quadrature body coil at 3.0T: a feasibility study. Eur Radiol. 2006 Aug 30;[epub]
  38. Korperich H, Gieseke J, Esdorn H, Peterschroder A, Hoogeveen R, Barth P, et al. Ultrafast time-resolved contrast-enhanced 3D pulmonary venous cardiovascular magnetic resonance angiography using SENSE combined with CENTRA-Keyhole. J Cardiovasc Magn Reson. 2007;9:77–87
  39. Vasbinder GB, Nelemans PJ, Kessels AG, Kroon AA, de Leeuw PW, van Engelshoven JM. Diagnostic tests for renal artery stenosis in patients suspected of having renovascular hypertension: a meta-analysis. Ann Intern Med. 2001;135:401–411
  40. Tan KT, van Beek EJ, Brown PW, van Delden OM, Tijssen J, Ramsay LE. Magnetic resonance angiography for the diagnosis of renal artery stenosis: a meta-analysis. Clin Radiol. 2002;57:617–624
  41. Vasbinder GB, Nelemans PJ, Kessels AG, Kroon AA, Maki JH, Leiner T, et al. Accuracy of computed tomographic angiography and magnetic resonance angiography for diagnosing renal artery stenosis. Ann Intern Med. 2004;141(9):674–682
  42. Leiner T, de Haan MW, Nelemans PJ, van Engelshoven JM, Vasbinder GB. Contemporary imaging techniques for the diagnosis of renal artery stenosis. Eur Radiol. 2005;15:2219–2229
  43. Schoenberg SO, Rieger J, Weber CH, Michaely HJ, Waggershauser T, Ittrich C, et al. High-spatial-resolution MR angiography of renal arteries with integrated parallel acquisitions: comparison with digital subtraction angiography and US. Radiology. 2005;235:687–698
  44. Dellegrottaglie S, Sanz J, Rajagopalan S. Technology insight: clinical role of magnetic resonance angiography in the diagnosis and management of renal artery stenosis. Nat Clin Pract Cardiovasc Med. 2006;3:329–338
  45. Michaely HJ, Schoenberg SO, Oesingmann N, Ittrich C, Buhlig C, Friedrich D, et al. Renal artery stenosis: functional assessment with dynamic MR perfusion measurements – feasibility study. Radiology. 2006;238:586–596
  46. Ho KY, Leiner T, de Haan MW, Kessels AG, Kitslaar PJ, van Engelshoven JM. Peripheral vascular tree stenoses: evaluation with moving-bed infusion-tracking MR angiography. Radiology. 1998 Mar;206(3):683–692
  47. Meaney JF, Ridgway JP, Chakraverty S, Robertson I, Kessel D, Radjenovic A, et al. Stepping-table gadolinium-enhanced digital subtraction MR angiography of the aorta and lower extremity arteries: preliminary experience. Radiology. 1999 Apr;211(1):59–67
  48. Ho KY, Leiner T, van Engelshoven JM. MR angiography of run-off vessels. Eur Radiol. 1999;9(7):1285–1289
  49. Meaney JF. Magnetic resonance angiography of the peripheral arteries: current status. Eur Radiol. 2003;13:836–852
  50. Deutschmann HA, Schoellnast H, Portugaller HR, Preidler KW, Reittner P, Tillich M, et al. Routine use of three-dimensional contrast-enhanced moving-table MR angiography in patients with peripheral arterial occlusive disease: comparison with selective digital subtraction angiography. Cardiovasc Intervent Radiol. 2006;29:762–770
  51. Gupta A, Frazer CK, Ferguson JM, Kumar AB, Davis SJ, Fallon MJ, et al. Acute pulmonary embolism: diagnosis with MR angiography. Radiology. 1999 Feb;210(2):353–359
  52. Oudkerk M, van Beek EJ, Wielopolski P, van Ooijen PM, Brouwers-Kuyper EM, Bongaerts AH, et al. Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. Lancet. 2002 May 11;359(9318):1643–1647
  53. Sheehy NP, Boyle GE, Meaney JF. Normal anterior spinal arteries within the cervical region: high-spatial-resolution contrast-enhanced three-dimensional MR angiography. Radiology. 2005 Aug;236(2):637–641
  54. Wall A, Kugel H, Bachman R, Matuszewski L, Kramer S, Heindel W, et al. 3.0T vs. 1.5T MR angiography: in vitro comparison of intravascular stent artifacts. J Magn Reson Imaging. 2005 Dec;22(6):772–779
  55. Knopp MV, von Tengg-Kobligk H, Floemer F, Schoenberg SO. Contrast agents for MRA: future directions. J Magn Reson Imaging. 1999;10:314–316
  56. Tombach B, Heindel W. Value of 1.0M gadolinium chelates: review of preclinical and clinical data on gadobutrol. Eur Radiol. 2002;12:1550–1556
  57. Goyen M, Edelman M, Perreault P, O'Riordan E, Bertoni H, Taylor J, et al. MR angiography of aortoiliac occlusive disease: a phase III study of the safety and effectiveness of the blood-pool contrast agent MS-325. Radiology. 2005;236:825–833
  58. Shamsi K, Yucel EK, Chamberlin P. A summary of safety of gadofosveset (MS-325) at 0.03mmol/kg body weight dose: phase II and phase III clinical trials data. Invest Radiol. 2006;41:822–830
  59. Goyen M, Debatin JF. Gadobenate dimeglumine (MultiHance) for magnetic resonance angiography: review of the literature. Eur Radiol. 2003 Nov;13(Suppl. 3):N19–N27
  60. Pediconi F, Fraioli F, Catalano C, Napoli A, Danti M, Francone M, et al. Gadobenate dimeglumine (Gd-DTPA) vs gadopentetate dimeglumine (Gd-BOPTA) for contrast-enhanced magnetic resonance angiography (MRA): improvement in intravascular signal intensity and contrast to noise ratio. Radiol Med (Torino). 2003 Jul–Aug;106(1–2):87–93
  61. Ohno Y, Higashino T, Takenaka D, Sugimoto K, Yoshikawa T, Kawai H, et al. MR angiography with sensitivity encoding (SENSE) for suspected pulmonary embolism: comparison with MDCT and ventilation–perfusion scintigraphy. Am J Roentgenol. 2004;183:91–98
  62. Kluge A, Luboldt W, Bachmann G. Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCT. Am J Roentgenol. 2006 Jul;187(1):W7–W14
  63. Berthezene Y, Croisille P, Wiart M, Howarth N, Houzard C, Faure O, et al. Prospective comparison of MR lung perfusion and lung scintigraphy. J Magn Reson Imaging. 1999;9:61–68
  64. Fink C, Puderbach M, Bock M, Lodemann KP, Zuna I, Schmahl A, et al. Regional lung perfusion: assessment with partially parallel three-dimensional MR imaging. Radiology. 2004;231:175–184
  65. Kluge A, Mueller C, Strunk J, Lange U, Bachmann G. Experience in 207 combined MRI examinations for acute pulmonary embolism and deep vein thrombosis. Am J Roentgenol. 2006 Jun;186(6):1686–1696
  66. Aschauer M, Deutschmann HA, Stollberger R, Hausegger KA, Obernosterer A, Schollnast H, et al. Value of a blood pool contrast agent in MR venography of the lower extremities and pelvis: preliminary results in 12 patients. Magn Reson Med. 2003;50:993–1002
  67. Sharafuddin MJ, Stolpen AH, Dang YM, Andresen KJ, Roh BS. Comparison of MS-325- and gadodiamide-enhanced MR venography of iliocaval veins. J Vasc Interv Radiol. 2002;13:1021–1027
  68. Fellner C, Strotzer M, Fraunhofer S, Held P, Spies V, Seitz J, et al. MR angiography of the supra-aortic arteries using a dedicated head and neck coil: image quality and assessment of stenoses. Neuroradiology. 1997;39:763–771
  69. Turski PA, Korosec FR, Carroll TJ, Willig DS, Grist TM, Mistretta CA. Contrast-enhanced magnetic resonance angiography of the carotid bifurcation using the time-resolved imaging of contrast kinetics (TRICKS) technique. Top Magn Reson Imaging. 2001;12:175–181
  70. Nederkoorn PJ, van der Graaf Y, Hunink MG. Duplex ultrasound and magnetic resonance angiography compared with digital subtraction angiography in carotid artery stenosis: a systematic review. Stroke. 2003;34:1324–1332
  71. Atlas SW, Sheppard L, Goldberg HI, Hurst RW, Listerud J, Flamm E. Intracranial aneurysms: detection and characterization with MR angiography with use of an advanced post-processing technique in a blinded-reader study. Radiology. 1997;203:807–814
  72. Duran M, Schoenberg SO, Yuh WT, Knopp MV, van Kaick G, Essig M. Cerebral arteriovenous malformations: morphologic evaluation by ultrashort 3D gadolinium-enhanced MR angiography. Eur Radiol. 2002;12:2957–2964
  73. Essig M, Reichenbach JR, Schad LR, Schoenberg SO, Debus J, Kaiser WA. High-resolution MR venography of cerebral arteriovenous malformations. Magn Reson Imaging. 1999;17:1417–1425
  74. Gelal FM, Kitis O, Calli C, Yunten N, Vidinli BD, Uygur M. Craniocervical artery dissection: diagnosis and follow-up with MR imaging and MR angiography. Med Sci Monit. 2004;10:MT109–MT116
  75. van der Laan MJ, Bakker CJG, Blankensteijn JD, Bartels LW. Dynamic CE-MRA for endoleak classification after endovascular aneursym repair. Eur J Vasc Endovasc Surg. 2006;31(2):130–135
  76. Ouwendijk R, Kock MC, van Dijk LC, van Sambeek MR, Stijnen T, Hunink MG. Vessel wall calcifications at multi-detector row CT angiography in patients with peripheral arterial disease: effect on clinical utility and clinical predictors. Radiology. 2006;241:603–608
  77. Ouwendijk R, Kock MC, Visser K, Pattynama PMT, de Haan MW, Hunink MG. Interobserver agreement for the interpretation of contrast-enhanced 3D MR angiography and MDCT in peripheral arterial disease. AJR Am J Roentgenol. 2005;185:1261–1276
  78. Rofsky NM. MR angiography of the aortoiliac and femoropopliteal vessels. Magn Reson Imaging Clin N Am. 1998 May;6(2):371–384
  79. Krinsky G, Jacobowitz G, Rofsky N. Gadolinium-enhanced MR angiography of extra-anatomic arterial bypass grafts. Am J Roentgenol. 1998;170(3):735–741
  80. Rofsky NM, Johnson G, Adelman MA, Rosen RJ, Krinsky GA, Weinreb JC. Peripheral vascular disease evaluated with reduced-dose gadolinium-enhanced MR angiography. Radiology. 1997 Oct;205(1):163–169
  81. Wang Y, Lee HM, Avakian R, Winchester PA, Khilnani NM, Trost D. Timing algorithm for bolus chase MR digital subtraction angiography. Magn Reson Med. 1998 May;39(5):691–696
  82. Wang Y, Winchester PA, Khilnani NM, Lee HM, Watts R, Trost DW, et al. Contrast-enhanced peripheral MR angiography from the abdominal aorta to the pedal arteries: combined dynamic two-dimensional and bolus-chase three-dimensional acquisitions. Invest Radiol. 2001 Mar;36(3):170–177
  83. Khilnani NM, Winchester PA, Prince MR, Vidan E, Trost DW, Bush HL, et al. Peripheral vascular disease: combined 3D bolus chase and dynamic 2D MR angiography compared with X-ray angiography for treatment planning. Radiology. 2002 Jul;224(1):63–74
  84. Korosec FR, Frayne R, Grist TM, Mistretta CA. Time-resolved contrast-enhanced 3D MR angiography. Magn Reson Med. 1996;36:345–351
  85. Mell M, Tefera G, Thornton F, Siepman D, Turnipseed W. Clinical utility of time-resolved imaging of contrast kinetics (TRICKS) magnetic resonance angiography for infrageniculate arterial occlusive disease. J Vasc Surg. 2007 Mar;45(3):543–548
  86. Thornton FJ, Du J, Suleiman SA, Dieter R, Tefera G, Pillai KR, et al. High-resolution, time-resolved MRA provides superior definition of lower-extremity arterial segments compared to 2D time-of-flight imaging. J Magn Reson Imaging. 2006 Aug;24(2):362–370
  87. Ho VB, Choyke PL, Foo TK, Hood MN, Miller DL, Czum JM, et al. Automated bolus chase peripheral MR angiography: initial practical experiences and future directions of this work-in-progress. J Magn Reson Imaging. 1999 Sep;10(3):376–388
  88. Wang Y, Chen CZ, Chabra SG, Winchester PA, Khilnani NM, Watts R, et al. Bolus arterial–venous transit in the lower extremity and venous contamination in bolus chase three-dimensional magnetic resonance angiography. Invest Radiol. 2002 Aug;37(8):458–463
  89. Prince MR, Chabra SG, Watts R, Chen CZ, Winchester PA, Khilnani NM, et al. Contrast material travel times in patients undergoing peripheral MR angiography. Radiology. 2002 Jul;224(1):55–61
  90. Zhang HL, Ho BY, Chao M, Kent KC, Bush HL, Faries PL, et al. Decreased venous contamination on 3D gadolinium-enhanced bolus chase peripheral MR angiography using thigh compression. Am J Roentgenol. 2004 Oct;183(4):1041–1047
  91. Wentz KU, Frohlich JM, von Weymarn C, Patak MA, Jenelten R, Zollikofer CL. High-resolution magnetic resonance angiography of hands with timed arterial compression (tac-MRA). Lancet. 2003 Jan 4;361(9351):49–50
  92. Ruehm SG, Goyen M, Barkhausen J, Kroger K, Bosk S, Ladd ME, et al. Rapid magnetic resonance angiography for detection of atherosclerosis. Lancet. 2001 Apr 7;357(9262):1086–1091
  93. Goyen M, Herborn CU, Kroger K, Ruehm SG, Debatin JF. Total-body 3D magnetic resonance angiography influences the management of patients with peripheral arterial occlusive disease. Eur Radiol. 2006 Mar;16(3):685–691Epub 2005 Sep 21
  94. Nael K, Ruehm SG, Michaely HJ, Saleh R, Lee M, Laub G, et al. Multistation whole-body high-spatial-resolution MR angiography using a 32-channel MR system. Am J Roentgenol. 2007 Feb;188(2):529–539
  95. Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann HJ. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol. 2005;40:715–724
  96. Hartmann M, Wiethoff AJ, Hentrich HR, Rohrer M. Initial imaging recommendations for Vasovist angiography. Eur Radiol. 2006;16(Suppl. 2):B15–B23
  97. Van Bemmel CM, Spreeuwers LJ, Viergever MA, Niessen WJ. Level-set-based artery–vein separation in blood pool agent CE-MR angiograms. IEEE Trans Med Imaging. 2003;22:1224–1234
  98. Lei T, Udupa JK, Odhner D, Nyúl LG, Saha PK. 3DVIEWNIX-AVS: a software package for the separate visualization of arteries and veins in CE-MRA images. Comput Med Imaging Graph. 2003;27:351–362
  99. Broome DR, Girguis MS, Baron PW, Cottrell AC, Kjellin I, Kirk GA. Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. Am J Roentgenol. 2007;188:586–592
  100. Majoie CB, Sprengers ME, van Rooij WJ, Lavini C, Sluzewski M, van Rijn JC, et al. MR angiography at 3T versus digital subtraction angiography in the follow-up of intracranial aneurysms treated with detachable coils. AJNR Am J Neuroradiol. 2005 Jun–Jul;26(6):1349–1356
  101. Markl M, Uhl M, Wieben O, Ness T, Langer M, Hennig J, et al. High resolution 3T MRI for the assessment of cervical and superficial cranial arteries in giant cell arteritis. J Magn Reson Imaging. 2006 Aug;24(2):423–427

PII: S1078-8174(07)00087-9

doi: 10.1016/j.radi.2007.09.002

Radiography
Volume 13 , Pages e31-e44 , December 2007

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