Diagnostic efficacy for coronary in-stent patency with parameters defined on Hounsfield CT value-spatial profile curves

Yamazaki, Tadashi; Suzuki, Jun-ichi; Shimamoto, Ryoichi; Tsuji, Taeko; Ohmoto-Sekine, Yuki; Morita, Toshihiro; Yamashita, Hiroshi; Honye, Junko; Nagai, Ryozo; Komatsu, Shuhei; Akahane, Masaaki; Ohtomo, Kuni

doi:10.1016/j.radi.2006.12.004

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Volume 14, Issue 2 , Pages 98-104, May 2008

Diagnostic efficacy for coronary in-stent patency with parameters defined on Hounsfield CT value-spatial profile curves

Tadashi Yamazaki
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Jun-ichi Suzuki
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
- Corresponding author. Laboratory Room-213, Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 1138655, Japan. Tel.: +81 3 3815 5411x33079; fax: +81 3 3814 0021.
Ryoichi Shimamoto
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Taeko Tsuji
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Yuki Ohmoto-Sekine
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Toshihiro Morita
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Hiroshi Yamashita
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Junko Honye
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Ryozo Nagai
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Shuhei Komatsu
- Department of Radiology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Masaaki Akahane
- Department of Radiology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Kuni Ohtomo
- Department of Radiology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Received 13 March 2006; accepted 8 December 2006.

Abstract

Purpose

Hounsfield CT values across coronary CT angiograms constitute CT value-spatial profile curves. These CT profile curves are independent of window settings, and therefore, parameters derived from the curves can be used for objective anatomic analyses. Applicability of parameters derived from the curves to quantification of coronary in-stent patency has not yet been evaluated.

Methods

Twenty-five CT value-spatial profile curves were delineated from 10 consecutive coronary stents to test correlation between the curve derived parameter (i.e., the minimum extreme value normalized by dividing by the maximum value of the curves obtained at neighboring outside of stents) and three intravascular ultrasound (IVUS) parameters.

Results

Correlation coefficients between normalized minimum extreme value of CT value-spatial profile curves and three IVUS parameters (such as patent cross-sectional in-stent area, the percentage of patent cross-sectional in-stent area, and coronary artery intra-stent diameter) were 0.65 (p<0.01), 0.44 (p<0.05) and 0.51 (p<0.05), respectively.

Conclusions

CT parameters defined on Hounsfield CT value-spatial profile curves correlated significantly with IVUS parameters for quantitative coronary in-stent patency. A new approach with CT coronary angiography is therefore indicated for the noninvasive assessment of in-stent re-stenosis.

Keywords: Coronary artery, Stent, Re-stenosis, Computed tomography